Correlation of endothelin-1 mRNA expression and bone structure in advanced osteoarthritis

摘要: Recent understandings of the vascular contribution pathophysiology osteoarthritis (OA) mount new evidence cross-talking between subchondral bone tissue and articular cartilage that might have a decisive role in Osteoarthritis (OA). These include blood flow (or interstitial fluid) impairment bone. With regard to mentioned vasculature, absence custom nourishing cartilage, established, vasoconstrictive endothelin-1 (ET-1) it was reasonable assume ET-1 has an inconvertible OA. Another moment OA is apoptosis osteocytes, what induces osteoclastic resorption at least temporarily reduces bony support for overlying cartilage. Since regional dependence this protein's expression presumed, we suggest division by histomorphometrical analysis quantification identified protein Real Time Polymerase Chain Reaction Analysis (RT-PCR). Obtained results should be compared serum levels soluble ET-1, would enforce methods validity. Herewith, screening marker patients with established. This enable detection follow-up groups threatened this, growing, cause disability decreased quality life.