How Protective Mechanisms Interact to Prevent Overnight Calcium Phosphate Precipitation - An Observational Study to Determine Factors Against Calcium Phosphate Lithogenesis in a Healthy Cohort.

摘要: Background/Aims: As restful, non-interrupted sleep is essential for normal mental and physical functioning, the urine flow rate (UFR) overnight remains low. Due to this reduced UFR, kidneys produce a lower volume, which may lead supersaturation of lithogens in renal collecting system. The protective mechanisms that prevent rise concentration lithogenic substances urine, such as calcium phosphate, are explored. Methods: Urine samples were collected from 26 subjects every 2-3 h during daylight with one nocturnal collection; UFR was calculated median time each collection period. Urinary constituents phosphate precipitation including electrolytes, calcium, citrate, pH measured. Comparisons within individuals done by paired t test. Results: excretion fell significantly (from 2.4 ± 0.2 µmol/min daytime 1.5 0.3 µmol/min, p Conclusions: Although overnight, there no evidence risk precipitate formation healthy increased.