Effects of Guanxinning Injection on Rat Cytochrome P450 Isoforms Activities in vivo and in vitro
作者： Yue Yu , Yan Liu , Qian Li , Jiahui Sun , Haiou Lin
DOI: 10.3109/00498254.2014.993002
关键词:
摘要: Abstract1. We aimed to investigate the regulatory effects of Guanxinning injection (GXNI) on activities cytochrome P1A2 (CYP1A2), CYP2C11, CYP2D1 and CYP3A1/2 by probe drugs in rats vivo vitro.2. GXNI-treated blank control groups were administered GXNI physiological saline caudal vein for 14 days consecutively, then they given caffeine (10 mg/kg), tolbutamide metoprolol (20 mg/kg) dapsone (10 mg/kg) intraperitoneal injection. The blood samples collected at different times ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis. Changes pharmacokinetics parameters between used evaluate four CYP450 isoforms vivo. After collection, livers taken made microsomes vitro tests. relevant metabolites phenacetin, tolbutamide, dextromethorphan testosterone analyzed ...
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