Repeated induction of abortion in bitches and the effect on plasma concentrations of relaxin, progesterone and estradiol-17β

摘要: The aim of the present study was to investigate effects two medications on subsequent abortions and plasma hormone concentrations dogs. For this purpose, groups bitches (n=5 each), received antiprogesterone aglepristone (Alizine) at 10mg/kg body weight days around day 30 after mating. In group II, antiprolactin cabergoline (Galastop) additionally administered po 5 microg/kg until start abortion. relaxin, progesterone (P4) estradiol-17beta (E2) were measured before, during each During next cycle abortion, same mated again in pregnant animals, induction abortion performed as before. third cycle, allowed whelp. Termination first pregnancy occurred significantly earlier combined treatment (6.8 versus 10.6 days, p 0.05). one bitch with high relaxin before (11.6 ng/ml), a cystic endometrial hyperplasia diagnosed. only group, P4 increased application (p At time, between 0.47 84.9 nmol/l both groups. level E2 over time not influenced by any medication. We therefore note that mainly different ways, probably due specific treatment-hormone interactions. However, all measurements fell within range considered normal.