Superantigen enhanced protection against a weak tumor-specific melanoma antigen: implications for prophylactic vaccination against cancer.

摘要: B16F10 melanoma is a tumor derived from C57BL/6 mice that has been found to be poorly immunogenic and highly aggressive. Here we have shown vaccination of with irradiated cells followed by treatment combination staphylococcal enterotoxins A B (SEA/SEB) leads significant specific protection against subsequent challenge viable (at least 25-fold greater than lethal dose). Also, 75% surviving over 150 days remained tumor-free after rechallenge cells, evidence the development strong immunologic memory. Additional studies showed increases in CD4+ CD8+ T-cell populations, cytotoxic T-lymphocyte activity interferon-γ production, all which may contribute enhanced survival. Furthermore, failure produce either CD4−/− or CD8−/− knockout T play an essential role induction immunity. These results show superantigen administration inactivated protective antitumor Thus, prophylactic cancer feasible method for arming immune system prior incidence cancer. © 2001 Wiley-Liss, Inc.