Pharmacokinetic interaction between telithromycin and metformin in diabetes mellitus rats.
作者： J. H. Lee , H. E. Kang , M. G. Lee
DOI: 10.3109/00498250903470248
关键词:
摘要: Telithromycin and metformin have been reported to be commonly metabolized via hepatic CYP3A1/2 in rats. Community-acquired respiratory tract infection was frequent patients with diabetes mellitus. Compared controls, increased male rats mellitus induced by streptozotocin (DMIS rats).After the intravenous administration of both drugs together DMIS rats, time-averaged non-renal clearance (CLNR) significantly slower (by 33.1%; 10.3 versus 15.4 ml min−1 kg−1) than alone due inhibition metabolism telithromycin CYP3A1/2.After oral together, total area under plasma concentration–time curve (AUC) comparable possibly intestinal telithromycin.
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