ERK Signaling Regulates Light-Induced Gene Expression via D-Box Enhancers in a Differential, Wavelength-Dependent Manner

摘要: The day-night and seasonal cycles are dominated by regular changes in the intensity as well spectral composition of sunlight. In aquatic environments spectrum sunlight is also strongly affected depth quality water. During evolution, organisms have adopted various key strategies order to adapt these changes, including development clocks photoreceptor mechanisms. These mechanisms enable detection anticipation lighting conditions thereby direct an appropriate physiological response. teleosts, a growing body evidence points most cell types possessing complex photoreceptive systems. However, our understanding precisely how systems regulated turn dictate gene expression remains incomplete. this manuscript we attempt unravel complexity comparing effects two specific wavelengths light upon signal transduction regulatory zebrafish cells. We reveal significant difference kinetics light-induced blue red exposure. Importantly, both relies D-box enhancer promoter elements. Using pharmacological genetic approaches demonstrate that ERK/MAPK pathway acts negative regulator but not activated transcription. Thus, D-box-driven via signaling wavelength-dependent manner.