Insights into the reasons for discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral naïve patients.

摘要: Objective: To evaluate the frequency of discontinuation first highly active antiretroviral regimen (HAART) and factors predictive discontinuing for toxicity failure in a population-based cohort HIV-positive individuals Italy, naive from antiretrovirals at enrolment.Methods: The study population consisted who initiated HAART had least one follow-up visit. primary end-points were any component drug failure. Survival analyses performed to identify reaching two end points.Results: Eight hundred sixty-two initialed HAART; 727 them (84.3%) this nucleoside reverse transcriptase inhibitors (NRTI) protease inhibitor (PI). Over median 45 weeks, 312 patients (36.2%) discontinued therapy: 182 (21.1%) due toxicity, 44 (5.1%) probability 1 year was 25.5% [95% confidence interval (Cl), 21.9-28.9] 7.6% (95% Cl, 4.9-10.3) Independent associated with were: gender [relative hazard (RH) = 0.51; 95% 0.32-0.80 men versus women], type treatment (indinavir-containing regimens, RH 1.94; 1.10-3.41 ritonavir-containing 3.83; 2.09-7.03 hard-gell saquinavir) time spent on (RH 0.89; 0.80-0.98 each additional month). Discontinuation independently most recent HIV-RNA 3.20; 959/0 1.74-5.88 log(10) copies/ml higher), 0.21; 0.06-0.78 0.23; 0.04-1.26 Versus saquinavir).Conclusions: If current caused no less than 10% discontinue their because after starting therapy. (C) 2000 Lippincatt Williams & Wilkins.