The outcome of pregnancies with confined placental chromosome mosaicism in cytotrophoblast cells.
作者： M. VERJAAL , K. HANSSON , H. WOLF , H. H. H. KANHAI , J. M. G. VAN VUGT
DOI: 10.1002/(SICI)1097-0223(199608)16:8<705::AID-PD930>3.0.CO;2-6
关键词:
摘要: Cytogenetic findings and outcome of pregnancy are reported in 108 cases which confined placental mosaicism (CPM, n = 101) or generalized (n 7) was found at after first-trimester chorionic villus sampling. In all samples, a (semi)direct cytogenetic analysis cytotrophoblast cells performed. Two pregnancies with CPM ended spontaneous abortion before 28 weeks (1.9 per cent). 15 the terminated: eight were shown to be examples CPM; seven can considered as mosaicism. A normal result obtained follow-up amniocentesis 88 remaining 91 cases. three cases, no performed but confirmation karyotype other cells. One nevertheless terminated for psychosocial reasons. child died perinatally another on seventh day birth. The birth weight is known 89 children; curve shows distribution. 11 these children (12.3 cent), below tenth centile. subgroup involvement chromosome 13, 16, 22, however, revealed two fetal losses four centile (75
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