Short-term synaptic plasticity across topographic maps in the electrosensory system.

摘要: The early pathways underlying the active electric sense of weakly fish Apteronotus leptorhynchus involve three parallel processing streams. An array tuberous electroreceptors distributed over skin provides inputs to electrosensory lateral line lobe (ELL), forming basis for topographic maps: LS (lateral segment), CLS (centrolateral and CMS (centromedial segment). In addition, each map receives topographically preserved from a direct feedback pathway. How this contributes distinct spatiotemporal filtering properties ELL pyramidal neurons across maps is not clear. We used an in vitro approach characterize short-term plasticity (STP) synapses onto map. Our findings indicated that dynamics STP varied manner was consistent with temporal vivo. Using modeling approach, we found best described by simple facilitation-depression model. On other hand, synaptic facilitation use-dependent recovery rate. These results suggest differential regulation overlapping processes can contribute functional specialization sensory maps.