Transgenic animals and methods of use

作者: Nigel Killeen , Matthias Wabl

DOI:

关键词:

摘要: The present invention comprises non-human vertebrate cells and mammals having a genome comprising an introduced partially human immunoglobulin region, said region VH coding sequences non-coding based on the endogenous of mammal.

参考文章(132)
Klaus Rajewsky, Andreas Ehlich, E. Al, Werner Muller, ALLELIC EXCLUSION MODEL QUESTIONED - REPLY ,(1992)
George Yancopoulos, Aris N. Economides, Samuel Davis, David M. Valenzuela, Genome mutation by intron insertion into an embryonic stem cell genome ,(2004)
J. E. Berman, S. J. Mellis, R. Pollock, C. L. Smith, H. Suh, B. Heinke, C. Kowal, U. Surti, L. Chess, C. R. Cantor, Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus. The EMBO Journal. ,vol. 7, pp. 727- 738 ,(1988) , 10.1002/J.1460-2075.1988.TB02869.X
Zhao-Qi Wang, Erwin Wagner, Method for developing transgenic mice ,(1997)
Michael J Gait, Oligonucleotide synthesis : a practical approach Published in <b>1984</b> in Oxford by IRL press. ,(1984)
John White, Radha Shah Parmar, Paul Andrew Hamblin, Multivalent and/or multispecific rankl-binding constructs ,(2010)
Ai-Sheng Xiong, Ri-He Peng, Jing Zhuang, Feng Gao, Yi Li, Zong-Ming Cheng, Quan-Hong Yao, Chemical gene synthesis: strategies, softwares, error corrections, and applications. Fems Microbiology Reviews. ,vol. 32, pp. 522- 540 ,(2008) , 10.1111/J.1574-6976.2008.00109.X
Marina Gertsenstein, Kristina Vintersten Nagy, Andras Nagy, Richard Behringer, Manipulating the Mouse Embryo: A Laboratory Manual ,(2002)
Christian Vettermann, Mark S. Schlissel, Allelic exclusion of immunoglobulin genes: models and mechanisms Immunological Reviews. ,vol. 237, pp. 22- 42 ,(2010) , 10.1111/J.1600-065X.2010.00935.X