Future directions in vitamin D and cardiovascular research

摘要: Abstract Aims Evidence is accumulating that vitamin D status may influence the risk of cardiovascular disease (CVD). Final confirmation for a causal relationship between and CVD however still lacking. The present viewpoint article outlines several future research directions to close this gap. Data synthesis Future include need performing large randomised controlled supplementation trials with in specific groups. In addition, register sets data on can be used, provided adequate statistical methods such as propensity score modelled analysis are applied. To better understand D-mediated effects risk, routine measurement circulating levels hormonal form, 1,25-dihydroxyvitamin D, also necessary, addition determination its precursor 25-hydroxyvitamin D. Further, genetic association studies help clarifying contribution development CVD. Finally, interrelationship physical activity should considered when studying risk. Conclusions Overall, it expected next 10–15 years will provide an increased clarity concerning role