Admixture mapping identifies introgressed genomic regions in North American canids

摘要: Hybrid zones typically contain novel gene combinations that can be tested by natural selection in a unique genetic context. Parental haplotypes increase fitness introgress beyond the hybrid zone, into range of parental species. We used Affymetrix canine SNP genotyping array to identify genomic regions tagged multiple ancestry informative markers are more frequent an admixed population than expected. surveyed zone formed last 100 years as coyotes expanded their eastern North America. Concomitant with expansion, hybridized wolves and some populations became wolflike, such northeast have largest body size any coyote population. Using set 3102 markers, we identified 60 differentially introgressed 44 canines across this admixture zone. These characterized excess exogenous and, northeastern coyotes, enriched for genes affecting skeletal proportions. Further, wolf-derived alleles penetrated Southern US populations. Because no currently exist area, these unlikely originated from recent hybridization. Instead, they probably intraspecific flow or ancient admixture. show grey wolf has far-reaching effects addition phenotypically transforming populations, allows differential movement different species new backgrounds.