Formation of Reactive Intermediates by Phase II Enzymes: Glutathione-Dependent Bioactivation Reactions
作者： Spyridon Vamvakas , M. W. Anders
DOI: 10.1007/978-1-4684-5877-0_2
关键词:
摘要: Xenobiotic metabolism serves several important functions in the body: The of drugs to pharmacologically inactive metabolites is major mechanism for termination drug action. Metabolism may quantitatively alter action and also convert prodrugs their active metabolites. In addition, xenobiotics polar, readily excretable a detoxication mechanism. Although chemicals usually beneficial, it now well known that toxicity most organic associated with enzymatic conversion toxic metabolites, process termed bioactivation (Anders, 1985).
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