Effects of T-2 mycotoxin ingestion on phagocytosis of Aspergillus fumigatus conidia by rabbit alveolar macrophages and on hematologic, serum biochemical, and pathologic changes in rabbits.

作者: Niyo Ka , Niyo Y , Richard Jl , Tiffany Lh

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摘要: Rabbits were given T-2 mycotoxin orally at 0, 0.25, 0.5, and 0.75 mg/kg of body weight/day for 21 days. Only rabbits in the mg/kg/day group (4 5 rabbits) died. Alveolar macrophages harvested on day 22 used vitro phagocytosis killed Aspergillus fumigatus conidia. Cultures included sera from untreated or treated with T-2. Phagocytosis was significantly (P less than 0.01) reduced cultures that serum 0.5 mg T-2/kg/day alveolar There little reduction when normal used. Ingestion toxin/kg/day 0.05) weight gain, alkaline phosphatase activity, sorbitol dehydrogenase bacteriostasis. Similar changes found group, as well a significant PCV, total WBC, differential leukocyte counts. Neutrophil counts decreased, but not (0.05 P 0.10). Significant detected alanine transaminase aspartate blood urea nitrogen concentration, complement hemolytic activity. Histopathologic consisting centrilobular hepatocellular swelling, mild portal periportal fibrosis lymphocyte necrosis within secondary lymphoid tissues developed most Thymic atrophy, bile duct reduplication, depletion mg/kg/day.(ABSTRACT TRUNCATED AT 250 WORDS)

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