Immunotoxicity of Trichothecene Mycotoxins

摘要: The trichothecene mycotoxins are sesquiterpene alcohols or esters. Several genera of imperfect fungi, including; Trichoderma, Trichothecium, Myrothecium, Stachybotrys, Cephalosporium, and Verticimonosporium known to produce mycotoxins, most notable, however, several Fusarium species. To date approximately 100 naturally occurring have been identified. However, the rarity has limited toxicology research, primarily, study of; 4-deoxynivalenol (DON, vomitoxin), 3-acetyl-deoxynivalenol (3-acetyl-DON), diacetoxyscirpenol (DAS, anguidine), fusarenon-X (FUS-X), nivalenol (NIV) , T-2 toxin (T-2). Often described as secondary, plant metabolites, without obvious benefit organism, believed be produced in response various environmental stresses. Trichothecene-producing fungi distributed widely, found temperate well subtropical climates.