Thermoresponsive Polypeptides from Pegylated Poly-l-glutamates
作者： Chongyi Chen , Zhaohui Wang , Zhibo Li , None
DOI: 10.1021/BM200849M
关键词:
摘要: The synthesis and characterization of new thermoresponsive pegylated poly-l-glutamate (poly-l-EGxGlu) are described. obtained polypeptides display low critical solution temperature (LCST) behaviors in water, the LCST can be tuned via copolymerization different amino acid monomers at varied molar ratio. This is first example polypeptide made from ring-opening polymerization α-amino N-carboxyanhydrides (NCAs). Circular dichroism characterizations reveal that secondary structure poly-l-EGxGlu depended on chain length side chain.
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