Sex and gender differences in myocardial hypertrophy and heart failure.
作者： Vera Regitz-Zagrosek , Ute Seeland
DOI: 10.1007/S10354-011-0892-8
关键词:
摘要: Cardiovascular disease is the most common cause of death in men and women worldwide. Men develop most, but not all, cardiovascular diseases at an earlier age while number affected significantly increases with higher age. Heart failure (HF) a carries poor prognosis both genders. Risk factors myocardial adaptations HF are different. Female hearts more favorable physiological form remodeling than male hearts. This may be related to sex hormones, estrogens testosterone. A clinical study for gender differences human aortic stenosis supports hypotheses. management differs between sexes, underdiagnosis undertreatment less use invasive therapies women. Nevertheless, frequently have better outcomes men. Gender research will contribute directly patient-oriented benefit by suggesting protocols.
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sci-hub.se 参考文章(74)
Vera Regitz-Zagrosek, Thomas Krabatsch, Elke Dworatzek, Roland Hetzer, Shokufeh Mahmoodzadeh, Elke B Lehmkuhl, George Petrov, Abstract 3549: Regression of Myocardial Hypertrophy After Aortic Valve Replacement: Faster In Women? Circulation. ,vol. 120, ,(2009)
Christian Grohé, Stefan Kahlert, Kerstin Löbbert, Michael Stimpel, Richard H. Karas, Hans Vetter, Ludwig Neyses, Cardiac myocytes and fibroblasts contain functional estrogen receptors FEBS Letters. ,vol. 416, pp. 107- 112 ,(1997) , 10.1016/S0014-5793(97)01179-4
Vera Regitz-Zagrosek, George Petrov, Elke Lehmkuhl, Jaqueline M. Smits, Birgit Babitsch, Claudia Brunhuber, Beate Jurmann, Julia Stein, Carola Schubert, Noel Bairey Merz, Hans Brendan Lehmkuhl, Roland Hetzer, Heart transplantation in women with dilated cardiomyopathy. Transplantation. ,vol. 89, pp. 236- 244 ,(2010) , 10.1097/TP.0B013E3181C35255
R H Karas, B L Patterson, M E Mendelsohn, Human vascular smooth muscle cells contain functional estrogen receptor Circulation. ,vol. 89, pp. 1943- 1950 ,(1994) , 10.1161/01.CIR.89.5.1943
Henning Witt, Carola Schubert, Juliane Jaekel, Daniela Fliegner, Adam Penkalla, Klaus Tiemann, Joerg Stypmann, Stefan Roepcke, Sebastian Brokat, Shokoufeh Mahmoodzadeh, Eva Brozova, Mercy M. Davidson, Patricia Ruiz Noppinger, Christian Grohé, Vera Regitz-Zagrosek, Sex-specific pathways in early cardiac response to pressure overload in mice. Journal of Molecular Medicine. ,vol. 86, pp. 1013- 1024 ,(2008) , 10.1007/S00109-008-0385-4
Christa Nöhammer, Friedrich Brunner, Gerald Wölkart, Philipp B Staber, Ernst Steyrer, Frank J Gonzalez, Rudolf Zechner, Gerald Hoefler, Myocardial Dysfunction and Male Mortality in Peroxisome Proliferator-Activated Receptor Alpha Knockout Mice Overexpressing Lipoprotein Lipase in Muscle Laboratory Investigation. ,vol. 83, pp. 259- 269 ,(2003) , 10.1097/01.LAB.0000053916.61772.CA
V REGITZZAGROSEK, T WINTERMANTEL, C SCHUBERT, Estrogens and SERMs in coronary heart disease Current Opinion in Pharmacology. ,vol. 7, pp. 130- 139 ,(2007) , 10.1016/J.COPH.2006.10.009
Jean-Yves Reginster, Miscellaneous and Experimental Agents The American Journal of the Medical Sciences. ,vol. 313, pp. 33- 40 ,(1997) , 10.1016/S0002-9629(15)40039-4
Vera Regitz-Zagrosek, Therapeutic implications of the gender-specific aspects of cardiovascular disease Nature Reviews Drug Discovery. ,vol. 5, pp. 425- 439 ,(2006) , 10.1038/NRD2032
Vera Regitz-Zagrosek, Sebastian Brokat, Carsten Tschope, Role of Gender in Heart Failure with Normal Left Ventricular Ejection Fraction Progress in Cardiovascular Diseases. ,vol. 49, pp. 241- 251 ,(2007) , 10.1016/J.PCAD.2006.08.011