Piper Sarmentosum Leaf as a Promising Non-Toxic Antiparasitic Agent against Trypanosoma Evansi-Induced Mice:

摘要: Realizing that Trypanosoma evansi is now has been potentially trans-infected to human from animals, this study demonstrated how the manipulation of natural plant, Piper sarmentosum, promisingly can solve endemicity vector-borne zoonotic manifestation atypical trypanosomiasis (AHT) and Surra disease in livestock. Groups male mice were intraperitoneally administered with parasite at 5.0 × 103 T. evansi/mouse orally given pre- post-infection treatments 0.2 mL 10 mg/mL P. sarmentosum-dH2O extract per mouse. By using Giemsa stained blood smear, development cells, toxicity level enzymes, histopathology selected organs survival rate investigated. The morphological changes cells evidenced a positive correlation (p ≤ 0.05, n = 6) recorded between time ability inhibit parasites growth pre-infection treatment group, PRE14. Besides, PRE14 group was also longest pre-patent period. enzymes significantly situated normal ranged no abnormalities found on organs. This sarmentosum could be manipulated as potential antiparasitic alternative drug towards trypanosomiasis.