Human serum lyses Trypanosoma brucei by triggering uncontrolled swelling of the parasite lysosome.
作者： BENOIT VANHOLLEBEKE , LAURENCE LECORDIER , DAVID PEREZ-MORGA , AMELIA AMIGUET-VERCHER , ETIENNE PAYS
DOI: 10.1111/J.1550-7408.2007.00285.X
关键词:
摘要: Trypanosoma brucei infects a wide range of mammals, but is unable to infect humans because this subspecies lysed by normal human serum (NHS). The phenotype cellular lysis debated. For some authors the lysosome undergoes osmotic swelling due massive influx chloride ions from cytoplasmic compartment, others describe multiple small vacuoles and general body. Using population-level imaging live immobilized trypanosomes throughout process, we report that specific genuine major characteristic NHS-mediated independent strain NHS aging or damaging. Thus, irrespective experimental conditions reproducibly induced parasite lysosome.
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