Tanshinone IIA protects against myocardial ischemia reperfusion injury by activating the PI3K/Akt/mTOR signaling pathway.
作者： Qiang Li , Li Shen , Zhen Wang , Hai-Peng Jiang , Li-Xia Liu
DOI: 10.1016/J.BIOPHA.2016.09.014
关键词:
摘要: Objective To determine the mechanism by which Tanshinone IIA (Tan IIA) relieves myocardial ischemia reperfusion injury (MIRI) in rats via the PI3K/Akt/mTOR signaling pathway. …
sci-hub.se 参考文章(30)
Prasanna Abeyrathna, Yunchao Su, The critical role of Akt in cardiovascular function Vascular Pharmacology. ,vol. 74, pp. 38- 48 ,(2015) , 10.1016/J.VPH.2015.05.008
Sumarno Rp, Sardjono Tw, Fitri Le, Simamora D, Setyawati Sk, High dose of N-acetylcysteine increase H₂O₂ and MDA levels and decrease GSH level of HUVECs exposed with malaria serum. Tropical Biomedicine. ,vol. 28, pp. 7- 15 ,(2011)
Qinghua Shang, Hao Xu, Li Huang, Tanshinone IIA: A Promising Natural Cardioprotective Agent. Evidence-based Complementary and Alternative Medicine. ,vol. 2012, pp. 716459- 716459 ,(2012) , 10.1155/2012/716459
Huilin Hu, Changlin Zhai, Gang Qian, Aiming Gu, Jialiang Liu, Fang Ying, Wenbo Xu, Dandan Jin, Huawei Wang, Haizhen Hu, Yingqing Zhang, Guanmin Tang, Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury by reducing oxidative stress, HMGB1 expression, and inflammatory reaction Pharmaceutical Biology. ,vol. 53, pp. 1752- 1758 ,(2015) , 10.3109/13880209.2015.1005753
Subhendu Mukherjee, Istvan Lekli, Manika Das, Angelo Azzi, Dipak K. Das, Cardioprotection with α-tocopheryl phosphate: Amelioration of myocardial ischemia reperfusion injury is linked with its ability to generate a survival signal through Akt activation Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. ,vol. 1782, pp. 498- 503 ,(2008) , 10.1016/J.BBADIS.2008.05.002
P Frost, Y Shi, B Hoang, A Lichtenstein, AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells Oncogene. ,vol. 26, pp. 2255- 2262 ,(2007) , 10.1038/SJ.ONC.1210019
Zhouguang Wang, Yue Wang, Junming Ye, Xianghong Lu, Yi Cheng, Lijun Xiang, Li Chen, Wenke Feng, Hongxue Shi, Xichong Yu, Li Lin, Hongyu Zhang, Jian Xiao, Xiaokun Li, bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischaemia/reperfusion via activation of PI3K/Akt/ERK1/2 pathway Journal of Cellular and Molecular Medicine. ,vol. 19, pp. 595- 607 ,(2015) , 10.1111/JCMM.12346
Aijun Xu, Karol Szczepanek, Michael W. Maceyka, Thomas Ross, Elizabeth Bowler, Ying Hu, Barrett Kenny, Chris Mehfoud, Pooja N. Desai, Clive M. Baumgarten, Qun Chen, Edward J. Lesnefsky, Transient complex I inhibition at the onset of reperfusion by extracellular acidification decreases cardiac injury American Journal of Physiology-cell Physiology. ,vol. 306, ,(2014) , 10.1152/AJPCELL.00241.2013
Sverre E. Aune, Daniel J. Herr, Santhosh K. Mani, Donald R. Menick, Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion Journal of Molecular and Cellular Cardiology. ,vol. 72, pp. 138- 145 ,(2014) , 10.1016/J.YJMCC.2014.03.005
Wei-Li Qiao, Differential expression of Bcl-2 and Bax during gastric ischemia-reperfusion of rats World Journal of Gastroenterology. ,vol. 17, pp. 1718- 1724 ,(2011) , 10.3748/WJG.V17.I13.1718