Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

作者: P. Schu , K Takegawa , M. Fry , J. Stack , M. Waterfield

DOI: 10.1126/SCIENCE.8385367

关键词:

摘要: … is known to interact with activated cell surface receptor tyrosine kinases. … VPS34 encodes a yeast PI 3-kinase, and this enzyme … To understand the molecular population genetics of this …

参考文章(31)
S.P. Soltoff, S.L. Rabin, L.C. Cantley, D.R. Kaplan, Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. Journal of Biological Chemistry. ,vol. 267, pp. 17472- 17477 ,(1992) , 10.1016/S0021-9258(18)41950-3
F. Shibasaki, Y. Homma, T. Takenawa, TWO TYPES OF PHOSPHATIDYLINOSITOL 3-KINASE FROM BOVINE THYMUS : MONOMER AND HETERODIMER FORM Journal of Biological Chemistry. ,vol. 266, pp. 8108- 8114 ,(1991) , 10.1016/S0021-9258(18)92948-0
K.R. Auger, C.L. Carpenter, L.C. Cantley, L Varticovski, Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae. Journal of Biological Chemistry. ,vol. 264, pp. 20181- 20184 ,(1989) , 10.1016/S0021-9258(19)47043-9
C L Carpenter, B C Duckworth, K R Auger, B Cohen, B S Schaffhausen, L C Cantley, Purification and characterization of phosphoinositide 3-kinase from rat liver. Journal of Biological Chemistry. ,vol. 265, pp. 19704- 19711 ,(1990) , 10.1016/S0021-9258(17)45429-9
J.M. Backer, M.G. Myers, S.E. Shoelson, D.J. Chin, X.J. Sun, M. Miralpeix, P. Hu, B. Margolis, E.Y. Skolnik, J. Schlessinger, Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. The EMBO Journal. ,vol. 11, pp. 3469- 3479 ,(1992) , 10.1002/J.1460-2075.1992.TB05426.X
R.L. Del Vecchio, P.F. Pilch, Phosphatidylinositol 4-kinase is a component of glucose transporter (GLUT 4)-containing vesicles. Journal of Biological Chemistry. ,vol. 266, pp. 13278- 13283 ,(1991) , 10.1016/S0021-9258(18)98835-6
D L Lips, P W Majerus, F R Gorga, A T Young, T L Benjamin, Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. Journal of Biological Chemistry. ,vol. 264, pp. 8759- 8763 ,(1989) , 10.1016/S0021-9258(18)81858-0
P Hu, B Margolis, E Y Skolnik, R Lammers, A Ullrich, J Schlessinger, Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Molecular and Cellular Biology. ,vol. 12, pp. 981- 990 ,(1992) , 10.1128/MCB.12.3.981