Active Compression-Decompression CPR Improves Vital Organ Perfusion in a Dog Model of Ventricular Fibrillation

摘要: Objectives This study was designed to assess whether a new method of cardiopulmonary resuscitation (CPR), termed active compression-decompression CPR, or ACD-CPR, improves organ perfusion when compared with standard (S) CPR in dog model ventricular fibrillation. Background ACD-CPR has recently been shown improve hemodynamic and respiratory parameters during cardiac arrest CPR. However, our knowledge, the effects on tissue have not investigated. Methods Ventricular fibrillation induced eight anesthetized, intubated animals. were each performed twice alternating order. All interventions preceded by 1 min fibrillation, which no performed, consisted 6 either technique measured. Compressions at 80/min 50 percent duty cycle 175 200 N downward force applied chest wall for both techniques. Epinephrine administered beginning 6-min interval. Hemodynamic monitoring aortic right atrial pressure continuously myocardial, cerebral, renal blood flows measured using radiolabeled microsphere baseline all interventions. Results Baseline hemodynamics similar dogs. left ventricular, brain, 62.0±5.5, 14.1±2.1, 476.3±55.5 ml/min/100 g, respectively (mean±SEM). Compared resulted higher global (22.5±6.2 vs 14.1±4.0 p Conclusions We conclude that systemic