Vital organ perfusion during assisted circulation by manipulation of intrathoracic pressure.

作者: N C Chandra , R Beyar , H R Halperin , J E Tsitlik , E Wurmb

DOI: 10.1161/01.CIR.84.1.279

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摘要: BACKGROUNDWe have previously shown, in dogs with severe cardiac depression, that modest cyclic increases intrathoracic pressure, starting synchronously left ventricular isovolumic contraction, significantly increase aortic flow and pressure. However, little is known of changes vital organ perfusion during this technique assisted circulation.METHODS AND RESULTSWe studied regional using radioactive labeled microspheres 13 20-25-kg mongrel dogs. In the control group, after chemical induction depression verapamil propranolol, coronary fell from 129.1 +/- 14.4 to 51.6 11.3 ml/100 g/min (p less than 0.005) continued decline over a 14-minute time period (flow was 32.2 11.5 at 7 minutes 20.7 9.5 14 [n = 6]; all p 0.05). intervention blood evaluated before also circulation 400-msec, 20-25-mm...

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