Neonatal bleeding in haemophilia: a European cohort study
作者： M. Richards , G. Lavigne Lissalde , C. Combescure , A. Batorova , G. Dolan
DOI: 10.1111/J.1365-2141.2011.08967.X
关键词:
摘要: Birth is the first haemostatic challenge for a child with haemophilia. Our aim was to examine association between perinatal risk factors and major neonatal bleeding in infants This observational cohort study 12 European haemophilia treatment centres (HTC) incorporated 508 children A or B, born 1990 2008. Risk were analysed by univariate analysis. Head bleeds occurred 18 (3·5%) within 28 d of life, including three intraparenchymal bleeds, one subdural haematoma 14 cephalohaematomas. Intra-cranial associated long-term neurological sequelae two (0·4%) cases; no deaths occurred. Assisted delivery (forceps/vacuum) only factor head [Odds Ratio (OR) 8·84: 95% confidence interval (CI) 3·05-25·61]. Mild maternal awareness her carrier status seemed be protective (OR 0·24; 95%CI 0·05-1·05 OR 0·34; 0·10-1·21, respectively), but due low number events this not statistically significant. We found country, age, parity, gestational age presence HTC. Maternal protected against assisted (unadjusted 0·37; 0·15-0·90; adjusted 0·47 (95%CI 0·18-1·21).
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