Clinical and laboratory approaches to hemophilia a.

摘要: Hemophilia A is a worldwide disorder of coagulation system. It male disorder, yet females with hemophilia are rarely seen in communities high rate consanguineous marriages. The abnormalities factor VIII gene transfer as an X-linked pattern the family, affects many one-third patients who had no family history abnormality and thus occurrence sporadic mutation could be documented. Hemorrhagic symptoms usually correlate plasma level comprise wide range hemorrhagic pictures, including from fatal spontaneous bleeding brain to ecchymosis skin. study needs differentiate between two types B well categorization disease severity. In developing countries, due limitations diagnostic hemostasis facilities scant number experts field, it estimated that noticeable numbers undiagnosed exist. Occasionally, we encounter cases by general physicians while having symptoms. purpose this review recap clinical parameters, pitfalls, interpretation assay A. literature was done PubMed Scopus medical search engines using keywords "Hemophilia" "Haemophilia". time limitation for publication beyond 1995 English language were considered. total 94 original articles chapters books selected current review. Additionally, comprehensive up-to-date information on laboratory features diagnosis also presented.