Endometrial and fetoplacental markers in pregnancies with fetal congenital nephrosis
作者： Seppo Heinonen , Markku Ryynänen , Pertti Kirkinen , Seppo Saarikoski
DOI: 10.3109/00016349609054665
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摘要: Objective. Congenital nephrotic syndrome of the Finnish type [CNF] is an autosomal recessive disorder leading to death in early childhood, if treated conservatively without renal transplantation. Prenatal screening at midtrimester feasible by measuring maternal serum alpha-fetoprotein [MSAFP], elevated amniotic fluid [AF] AFP being only diagnostic test population screening. We studied whether concentrations other pregnancy-related markers offer any ancillary procedure for screening.Methods. In a prospective case-control study, human chorionic gonadotropin [hCG], unconjugated estriol [uE3], placental lactogen [hPL] and protein 14 [pp14] were measured samples from six singleton pregnancies associated with fetal CNF 18 matched controls 15 weeks gestation.Results. group, mean hCG pp slightly elevated, whereas uE3 hPL within lower normal range. None thes...
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