Kinetics of memory consolidation: role of amnesic treatment parameters.

摘要: Abstract The consolidation theory states that with the passage of time engram a recent learning experience grows increasingly resistant to disruption by amnesic treatment. The required reach complete resistance (“consolidation time”) is controversial issue; current estimates range from 101 105 seconds. present study suggests parsimonious interpretation divergence, namely, weak treatments fail block memory but do slow its rate, so post-treatment inflates retention scores measured 24 hours later and leads variably shortened “consolidation times.” This utilized 2880 neonate chicks trained in one-trial avoidance paradigm. Retrograde amnesia was induced treatment flurothyl (CF3CH2-OCH2CF3) vapor. Apparent times” determined conventional data analysis varied widely as function concentration exposure time, ranging 4 minutes under conditions (0.85% flurothyl; 1-min exposure) strong (1.7% 8-min exposure). With 1.7% flurothyl, half-time found be 9.8 hours.