Ethical considerations in bone tissue-engineered products

作者: Whit Froehlich , Owen Brown , Christian Vercler

DOI: 10.1016/B978-0-08-102451-5.00018-4

关键词:

摘要: Abstract Bone tissue-engineered products (BTEPs) are a therapeutic category that intersects with several areas of traditional ethical interest, as their implementation involves donated human cells, surgery, heavy cost research and development, potentially complex management. We briefly review the fundamental principles medical ethics then identify notable aspects application to BTEP technology, including sourcing cells used in production, performance research, characteristics therapy itself. Our discussion includes summary constituents continues properties an item donation, legal status, challenges commercializing results; ethics, conflicts use for research; distribution availability BTEPs, well limitations surgical applications. Ultimately, these considerations do not necessitate proscription; both BTEPs can be undertaken ethically, but should performed appropriate attention many issues they raise.

参考文章(37)
Hernando Abaunza, Klaus Romero, Elements for Adequate Informed Consent in the Surgical Context World Journal of Surgery. ,vol. 38, pp. 1594- 1604 ,(2014) , 10.1007/S00268-014-2588-X
Amir Reza Amiri, Kavitha Kanesalingam, Suzie Cro, Adrian T.H. Casey, Does source of funding and conflict of interest influence the outcome and quality of spinal research The Spine Journal. ,vol. 14, pp. 308- 314 ,(2014) , 10.1016/J.SPINEE.2013.10.047
James M. Anderson, Analiz Rodriguez, David T. Chang, Foreign body reaction to biomaterials. Seminars in Immunology. ,vol. 20, pp. 86- 100 ,(2008) , 10.1016/J.SMIM.2007.11.004
Peter Angelos, None, Surgical ethics and the challenge of surgical innovation American Journal of Surgery. ,vol. 208, pp. 881- 885 ,(2014) , 10.1016/J.AMJSURG.2014.09.013
G. Bahadur, M. Morrison, L. Machin, Beyond the ‘embryo question’: human embryonic stem cell ethics in the context of biomaterial donation in the UK Reproductive Biomedicine Online. ,vol. 21, pp. 868- 874 ,(2010) , 10.1016/J.RBMO.2010.10.001
Hannah B. Baker, John P. McQuilling, Nancy M.P. King, Ethical considerations in tissue engineering research: Case studies in translation Methods. ,vol. 99, pp. 135- 144 ,(2016) , 10.1016/J.YMETH.2015.08.010
Laura M Beskow, None, Lessons from HeLa Cells: The Ethics and Policy of Biospecimens Annual Review of Genomics and Human Genetics. ,vol. 17, pp. 395- 417 ,(2016) , 10.1146/ANNUREV-GENOM-083115-022536
T. Bubela, G. A. FitzGerald, E. R. Gold, Recalibrating Intellectual Property Rights to Enhance Translational Research Collaborations Science Translational Medicine. ,vol. 4, ,(2012) , 10.1126/SCITRANSLMED.3003490
Karen J.L Burg, Scott Porter, James F Kellam, Biomaterial developments for bone tissue engineering Biomaterials. ,vol. 21, pp. 2347- 2359 ,(2000) , 10.1016/S0142-9612(00)00102-2
Barrie R. Cassileth, Robert V. Zupkis, Katherine Sutton-Smith, Vicki March, Informed Consent — Why Are Its Goals Imperfectly Realized? New England Journal of Medicine. ,vol. 302, pp. 896- 900 ,(1980) , 10.1056/NEJM198004173021605