The potential tumor suppressor p73 differentially regulates cellular p53 target genes.

作者: Wenjing Zhou , Jieyuan Jiang , Jianhui Zhu , Xinbin Chen

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摘要: p73, a potential tumor suppressor, is p53 homologue. Transient over expression of p73 in cells can induce apoptosis and p21, cellular target gene primarily responsible for p53-dependent cell cycle arrest. To further characterize the role suppression, we established several groups lines that inducibly express under tetracycline-regulated promoter. By using these lines, found both arrest apoptosis. We also activate some but not all previously identified genes. Furthermore, transcriptional activities p53, alpha, beta to their common genes differ among one another. These results suggest similar different from signaling pathways leading suppression.

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