Estrogens, MSI and Lynch syndrome-associated tumors.
作者： Ana Monteiro Ferreira , Helga Westers , André Albergaria , Raquel Seruca , Robert M.W. Hofstra
DOI: 10.1016/J.BBCAN.2009.06.004
关键词:
摘要: Estrogens play a major role in the biology of hormone-responsive tissues but also normal physiology various non-typical tissues. In disease, estrogens have been associated with tumor development, particular tumors such as breast, endometrium, ovary and prostate. this paper we will review molecular mechanisms by which are involved cancer special focus Lynch syndrome related neoplasia. Further, discuss might on cell proliferation apoptosis, how metabolites can induce DNA damage possible connection between changes (hypo- hyper) methylation. address protective effect that high levels MMR neoplasias.
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