Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors.

摘要: Mutations in the k-ras and TP53 genes, as well microsatellite instability (MIN), are frequent genetic alterations colorectal carcinomas represent 3 different mechanisms carcinogenic process. Both incidence of cancer frequency such tumours have been related to clinico-pathological variables, including age gender patient location tumour. A number studies also reported associations between types alterations. We therefore wanted explore relationship these variables using multivariate analysis on material from 282 carcinomas. Three logistic regression models were constructed: 1) presence K-ras mutations was dependent MIN patient, with an especially low among younger males (overall p = 0.0003); 2) only tumour location, a positive association cancers occurring distally (p 0.002); 3) age, mutations, location. most male older female patients, rare or found almost exclusively proximal colon < 0.0001). Our data confirm that pathways dominate distal segments bowel suggest K-ras- MIN-dependent influenced by sex-related factors. Int. J. Cancer 74:664–669, 1997.© 1997 Wiley-Liss, Inc.