Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States)

摘要: Objective: The association between body mass index (BMI) and colon cancer has been reported to be different for men women. No prior literature examined if estrogen influences these differences. Methods: Using data from an incident population-based case (n = 1972) control 2386) study of we evaluated modifies the BMI risk cancer. Results: Women who were estrogen-negative (postmenopausal women not taking hormone replacement therapy, HRT) at increased regardless indicator status used (i.e. compared estrogen-positive defined as either being premenopausal or postmenopausal using HRT, OR 1.54, 95% CI 1.23–1.93; no recent exposure estrogens current HRT use within past 2 years, 1.58, 1.24–2.00; currently 1.65, 1.29–2.12). (kg/m2) was associated with among estrogen-negative. However, experienced a greater than two-fold increase in they had > 30 relative those <23 (for estrogen-positive, OR, 2.50, 1.51–4.13; premenopausal, 2.19, 0.94–5.07; 3.36, 1.58–7.13). Among decreased advancing age. Physical activity modified large BMI. Conclusions: These suggest importance etiology. Being resulted significant significantly estrogen-positive. We hypothesize that up-regulates IGF-I receptors IRS-I levels colon, which turn increases susceptibility obesity-induced insulin. further androgens may have similar effects given decline