Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction.

摘要: Patients with hypopituitarism develop a phenotype similar to metabolic syndrome central obesity and diabetes. Similarly, patients hypothalamic damage may obesity, insulin resistance, hyperphagia. We sought examine the clinical associations between hypopituitarism, dysfunction, nonalcoholic fatty liver disease (NAFLD). A case series of seen at our institution diagnoses or craniopharyngioma NAFLD was undertaken. Clinical, laboratory, biopsy features were reviewed. Twenty-one identified. diagnosed 6.4 +/- 7.5 years (median 3 years) after diagnosis hypothalamic/pituitary dysfunction. Mean gain in body mass index (BMI) 11.3 8.9 kg/m(2) an average yearly rate 2.2 kg/m(2). The majority developed elevated glucose levels dyslipidemia by time NAFLD. Of 10 biopsied, six cirrhotic, two had steatohepatitis (NASH) fibrosis, simple steatosis. Long-term follow-up 66 33 months (range 12-120) available for 18 patients. Two required transplantation. Six died, from related causes. In conclusion, and/or pituitary are risk excessive weight gain, impaired tolerance, subsequent development This group has high prevalence cirrhosis placing them liver-related death. novel evidence that dysfunction be accompanied progressive important implications work-up management disease.