Growth hormone therapy and its relationship to insulin resistance, glucose intolerance and diabetes mellitus: a review of recent evidence.

摘要: It is widely recommended that consideration should be given to the therapeutic use of growth hormone (GH) in adults with GH deficiency, whether condition childhood or adult onset. One reason for this recommendation possibility such treatment may reduce excess cardiovascular risk which associated hypopituitarism. This has been well documented, mortality ratios 1.7 2.2 being quoted different studies, and a result insulin resistance occurs However, it also suggested itself especially as deficiency accompanied by suggestive morphological features central adiposity. There is, however, no direct evidence increase hypopituitarism only prospective study designed examine relationship failed find statistically significant correlation between two. Since administration have an independent adverse effect on sensitivity could thus cause theoretical worsening risk, important review observed effects carbohydrate metabolism practice.