Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease
作者： Jonathan C. Cohen , Eric Boerwinkle , Thomas H. Mosley , Helen H. Hobbs
DOI: 10.1056/NEJMOA054013
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摘要: Background A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk coronary heart disease (CHD), but the effect lifelong reductions in LDL not known. We examined DNA-sequence variations that reduce levels on incidence events a large population. Methods compared CHD (myocardial infarction, fatal CHD, or revascularization) over 15-year interval Atherosclerosis Risk Communities study according to presence absence sequence variants proprotein convertase subtilisin/kexin type 9 serine protease gene (PCSK9) are cholesterol. Results Of 3363 black subjects examined, 2.6 percent had nonsense mutations PCSK9; these were 28 reduction mean and an 88 (P=0.008 for reduction; hazard ratio...
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