Glycosphingolipid patterns of the gastrointestinal tract and feces of germ-free and conventional rats.
作者： N Strömberg , S Teneberg , J Thurin , B E Gustafsson , K A Karlsson
DOI: 10.1016/S0021-9258(18)66866-8
关键词:
摘要: Acid and non-acid glycosphingolipids of stomach, small large intestine, stimulated feces germ-free conventional rats the same stain have been isolated characterized. The glycosphingolipid patterns intestinal organs were chemically immunologically very similar between two groups relatively unaffected by presence an microbial flora. major exception was hematoside with N-glycoloylneuraminic acid (NeuGc) (NeuGc alpha 2----3Gal beta 1----4Glc 1----1Cer) in stomach not found animals. Glycosphingolipids animals derived from epithelial cells mainly intestine showed no signs degradation. completely retained pattern blood group A-, B-, H-active glycolipids as sterile but contained less more lactosylceramide. This effect probably due to degradation bacteria, demonstrated vitro production lactosylceramide after treatment neuraminidase Clostridium perfringens. amount total per dry weight for 50% higher 300% compared Due amounts mucins 12% than feces. However, calculated rat day animal excreted (1.8 1.2 mg, respectively).
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