Disulfide-bridged cleavable PEGylation in polymeric nanomedicine for controlled therapeutic delivery.
作者： Haiqing Dong , Min Tang , Yan Li , Yongyong Li , Dong Qian
DOI: 10.2217/NNM.15.38
关键词:
摘要: PEGylation in polymeric nanomedicine has gained substantial predominance biomedical applications due to its resistance protein absorption, which is critically important for a therapeutic delivery system blood circulation. The shielding layer of PEGylation, however, creates significant steric hindrance that negatively impacts cellular uptake and intracellular distribution at the target site. This unexpected effect compromises biological efficacy encapsulated payload. To address this issue, one key strategies tether disulfide bond PEG constructing disulfide-bridged cleavable PEGylation. reversible can be cleaved enable selective detachment. article provides an overview on strategy, method progress nanosystem with bond.
sci-hub.se 参考文章(95)
Jean-Pierre Gillet, Michael M. Gottesman, Mechanisms of Multidrug Resistance in Cancer Methods in Molecular Biology. ,vol. 596, pp. 47- 76 ,(2010) , 10.1007/978-1-60761-416-6_4
Takashi Miyata, Noriko Asami, Tadashi Uragami, A reversibly antigen-responsive hydrogel Nature. ,vol. 399, pp. 766- 769 ,(1999) , 10.1038/21619
Deniz Ozdil, Halil Murat Aydin, Polymers for medical and tissue engineering applications Journal of Chemical Technology & Biotechnology. ,vol. 89, pp. 1793- 1810 ,(2014) , 10.1002/JCTB.4505
Yang Lei, Jing Wang, Cao Xie, Ernst Wagner, Weiyue Lu, Ying Li, Xiaoli Wei, Jibin Dong, Min Liu, Glutathione-sensitive RGD-poly(ethylene glycol)-SS-polyethylenimine for intracranial glioblastoma targeted gene delivery. Journal of Gene Medicine. ,vol. 15, pp. 291- 305 ,(2013) , 10.1002/JGM.2726
Jay L. Zweier, Arturo J. Cardounel, Murali C. Krishna, Kenichi Yamada, James B. Mitchell, Govindasamy Ilangovan, Haiquan Li, Periannan Kuppusamy, Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels. Cancer Research. ,vol. 62, pp. 307- 312 ,(2002)
Filomena G. Ottaviano, Diane E. Handy, Joseph Loscalzo, Redox regulation in the extracellular environment Circulation. ,vol. 72, pp. 1- 16 ,(2008) , 10.1253/CIRCJ.72.1
Yinan Zhong, Weijing Yang, Huanli Sun, Ru Cheng, Fenghua Meng, Chao Deng, Zhiyuan Zhong, Ligand-directed reduction-sensitive shell-sheddable biodegradable micelles actively deliver doxorubicin into the nuclei of target cancer cells. Biomacromolecules. ,vol. 14, pp. 3723- 3730 ,(2013) , 10.1021/BM401098W
Kihoon Nam, Hye Yeong Nam, Pyung-Hwan Kim, Sung Wan Kim, Paclitaxel-conjugated PEG and arginine-grafted bioreducible poly (disulfide amine) micelles for co-delivery of drug and gene. Biomaterials. ,vol. 33, pp. 8122- 8130 ,(2012) , 10.1016/J.BIOMATERIALS.2012.07.031
Can Cui, Ya-Nan Xue, Ming Wu, Yang Zhang, Ping Yu, Lei Liu, Ren-Xi Zhuo, Shi-Wen Huang, Cellular uptake, intracellular trafficking, and antitumor efficacy of doxorubicin-loaded reduction-sensitive micelles Biomaterials. ,vol. 34, pp. 3858- 3869 ,(2013) , 10.1016/J.BIOMATERIALS.2013.01.101
Atul Kolate, Dipesh Baradia, Sushilkumar Patil, Imran Vhora, Girish Kore, Ambikanandan Misra, PEG — A versatile conjugating ligand for drugs and drug delivery systems Journal of Controlled Release. ,vol. 192, pp. 67- 81 ,(2014) , 10.1016/J.JCONREL.2014.06.046