Correlation of Diffusion Tensor and Dynamic Perfusion MR Imaging Metrics in Normal-Appearing Corpus Callosum: Support for Primary Hypoperfusion in Multiple Sclerosis

摘要: BACKGROUND AND PURPOSE: Hypoperfusion of the normal-appearing white matter in multiple sclerosis (MS) may be related to ischemia or secondary hypometabolism from wallerian degeneration (WD). This study evaluated whether correlating perfusion and diffusion tensor imaging (DTI) metrics corpus callosum could provide support for an ischemic mechanism hypoperfusion. MATERIALS METHODS: Fourteen patients with relapsing-remitting MS (RRMS) 17 control subjects underwent MR DTI. Absolute measures cerebral blood volume (CBV), flow (CBF), mean transit time (MTT) were calculated. Mean diffusivity (MD) fractional anisotropy (FA) maps computed DTI data. After visual coregistration images, regions interest placed genu, central body, splenium callosum. Pearson product-moment correlation coefficients calculated using each region. RESULTS: In RRMS group, CBF CBV significantly correlated MD ( r = 0.83 0.63, respectively; both P 0.86 0.65, 0.23 0.25, is nonsignificant). No significant correlations found between MTT FA any measure group. subjects. CONCLUSION: RRMS, decreasing MD. These findings are more consistent what would expected primary than hypoperfusion WD.