Allosteric functioning of dimeric class C G‐protein‐coupled receptors
作者： J-P. Pin , J. Kniazeff , J. Liu , V. Binet , C. Goudet
DOI: 10.1111/J.1742-4658.2005.04728.X
关键词:
摘要: Whereas most membrane receptors are oligomeric entities, G-protein-coupled have long been thought to function as monomers. Within the last 15 years, accumulating data indicated that can form dimers or even higher ordered oligomers, but general functional significance of this phenomena is not yet clear. Among large receptor family, class C represent a well-recognized example constitutive dimers, both subunits being linked, in cases, by disulfide bridge. In review article, we show multidomain proteins and highlight importance their dimerization for activation. We illustrate several consequences terms specific properties drug development.
sci-hub.se 参考文章(45)
Xianghua Liu, Quanyuan He, David J. Studholme, Qi Wu, Songping Liang, Long Yu, NCD3G: a novel nine-cysteine domain in family 3 GPCRs Trends in Biochemical Sciences. ,vol. 29, pp. 458- 461 ,(2004) , 10.1016/J.TIBS.2004.07.009
C. Goudet, F. Gaven, J. Kniazeff, C. Vol, J. Liu, M. Cohen-Gonsaud, F. Acher, L. Prezeau, J. P. Pin, Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 378- 383 ,(2004) , 10.1073/PNAS.0304699101
Robert Fredriksson, Malin C. Lagerström, Lars-Gustav Lundin, Helgi B. Schiöth, The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families : Phylogenetic Analysis, Paralogon Groups, and Fingerprints Molecular Pharmacology. ,vol. 63, pp. 1256- 1272 ,(2003) , 10.1124/MOL.63.6.1256
Greg Nelson, Jayaram Chandrashekar, Mark A Hoon, Luxin Feng, Grace Zhao, Nicholas JP Ryba, Charles S Zuker, None, An amino-acid taste receptor Nature. ,vol. 416, pp. 199- 202 ,(2002) , 10.1038/NATURE726
Thierry Galvez, Béatrice Duthey, Julie Kniazeff, Jaroslav Blahos, Giorgio Rovelli, Bernhard Bettler, Laurent Prézeau, Jean-Philippe Pin, Allosteric interactions between GB1 andGB2 subunits are required for optimalGABAB receptor function The EMBO Journal. ,vol. 20, pp. 2152- 2159 ,(2001) , 10.1093/EMBOJ/20.9.2152
Thierry Galvez, Stephan Urwyler, Laurent Prézeau, Johannes Mosbacher, Cécile Joly, Barbara Malitschek, Jakob Heid, Isabelle Brabet, Wolfgang Froestl, Bernhard Bettler, Klemens Kaupmann, Jean-Philippe Pin, Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit. Molecular Pharmacology. ,vol. 57, pp. 419- 426 ,(2000) , 10.1124/MOL.57.3.419
Julie Kniazeff, Thierry Galvez, Gilles Labesse, Jean-Philippe Pin, No Ligand Binding in the GB2 Subunit of the GABABReceptor Is Required for Activation and Allosteric Interaction between the Subunits The Journal of Neuroscience. ,vol. 22, pp. 7352- 7361 ,(2002) , 10.1523/JNEUROSCI.22-17-07352.2002
Fiona H Marshall, Kenneth A Jones, Klemens Kaupmann, Bernhard Bettler, GABAB receptors – the first 7TM heterodimers Trends in Pharmacological Sciences. ,vol. 20, pp. 396- 399 ,(1999) , 10.1016/S0165-6147(99)01383-8
Joel Bockaert, Jean Philippe Pin, Molecular tinkering of G protein‐coupled receptors: an evolutionary success The EMBO Journal. ,vol. 18, pp. 1723- 1729 ,(1999) , 10.1093/EMBOJ/18.7.1723
Yuji Tsuji, Yoshimi Shimada, Tomoko Takeshita, Naoko Kajimura, Sayuri Nomura, Naohiro Sekiyama, Jun Otomo, Jiro Usukura, Shigetada Nakanishi, Hisato Jingami, Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1. Journal of Biological Chemistry. ,vol. 275, pp. 28144- 28151 ,(2000) , 10.1074/JBC.M003226200