Evidence for a pseudoautosomal locus for schizophrenia. II: Replication of a non-random segregation of alleles at the DXYS14 locus.
作者： T. D'Amato , D. Campion , Ph. Gorwood , M. Jay , O. Sabate
DOI: 10.1192/BJP.161.1.59
关键词:
摘要: Because of an association between sexual aneuploidies and schizophrenia, because schizophrenic siblings have been found to be more often the same than opposite sex, susceptibility locus for schizophrenia is thought lie within pseudoautosomal region sex chromosomes. We analysed 33 sibships comprising 18 pairs, 13 trios, 2 quartets affected siblings, support non-random segregation alleles at DXYS14 in siblings. These findings are consistent with hypothesis favour a genetic linkage disease.
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