Joint influence of small-effect genetic variants on human longevity

摘要: The results of genome-wide association studies complex traits, such as life span or age at onset chronic disease, suggest that traits are typically affected by a large number small-effect alleles. Individually alleles have little predictive values, therefore they were usually excluded from further analyses. our study strongly the with small individual effects on longevity may jointly influence so resulting can be both substantial and significant. We show this joint described relatively simple “genetic dose - phenotypic response” relationship.