Serum advanced glycation endproducts are associated with left ventricular dysfunction in normal glucose metabolism but not in type 2 diabetes: The Hoorn Study.
作者： Pauline BC Linssen , Ronald MA Henry , Casper G Schalkwijk , Jacqueline M Dekker , Giel Nijpels
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摘要: Objective:To investigate whether serum advanced glycation endproducts are associated with left ventricular systolic and diastolic function in participants normal glucose metabolism, impaired metabolism type 2 diabetes mellitus.Methods:Participants from a cross-sectional, population-based study (n = 280 n = 171 n = 242 mellitus) underwent echocardiography. Serum protein-bound [i.e. Ne-(carboxymethyl)lysine, pentosidine Ne-(carboxyethyl)lysine] were measured. Linear regression analyses used stratified according to status.Results:In higher Ne-(carboxymethyl)lysine levels worse (left atrial volume index volume × left mass product term) Ne-(carboxyethyl)lysine funct...
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