The role of the orphan G protein-coupled receptor 37 (GPR37) in multiple myeloma cells.
作者： Xianting Huang , Yuchan Wang , Xun Nan , Song He , Xiaohong Xu
DOI: 10.1016/J.LEUKRES.2013.11.007
关键词:
摘要: The orphan G protein-coupled receptor 37 (GPR37) is homologous to endothelin (ETB-R) and bombesin (GRP-R, NMB-R) receptors. present study was undertaken determine the expression functional significance of GPR37 in human multiple myeloma (MM). We found that lowly expressed MM cell adhesion model highly proliferating cells. In vitro, meddling with affected CAM-DR by regulating ability activity Akt ERK Further studies indicated positive role proliferation
sci-hub.se 参考文章(46)
Meng-chang WANG, Xue-de FU, Man-xiang LI, PI-3K/Akt/GSK-3beta signaling cascades stimulated by insulin like growth factor-I contribute to multiple myeloma cells proliferation and survival. Chinese Medical Journal. ,vol. 119, pp. 1226- 1229 ,(2006) , 10.1097/00029330-200607020-00018
Mel B Feany, Leo J Pallanck, Parkin: A Multipurpose Neuroprotective Agent? Neuron. ,vol. 38, pp. 13- 16 ,(2003) , 10.1016/S0896-6273(03)00201-0
Klaus Podar, Alexander Zimmerhackl, Mariateresa Fulciniti, Giovanni Tonon, Ursula Hainz, Yu-Tzu Tai, Sonia Vallet, Niels Halama, Dirk Jäger, Dian L. Olson, Martin Sattler, Dharminder Chauhan, Kenneth C. Anderson, The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications British Journal of Haematology. ,vol. 155, pp. 438- 448 ,(2011) , 10.1111/J.1365-2141.2011.08864.X
Lori A. Hazlehurst, William S. Dalton, Mechanisms associated with cell adhesion mediated drug resistance (CAM-DR) in hematopoietic malignancies. Cancer and Metastasis Reviews. ,vol. 20, pp. 43- 50 ,(2001) , 10.1023/A:1013156407224
Jason S. Damiano, Anne E. Cress, Lori A. Hazlehurst, Alexander A. Shtil, William S. Dalton, Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines Blood. ,vol. 93, pp. 1658- 1667 ,(1999) , 10.1182/BLOOD.V93.5.1658
Kenneth H. Shain, Terry H. Landowski, William S. Dalton, Adhesion-Mediated Intracellular Redistribution of c-Fas-Associated Death Domain-Like IL-1-Converting Enzyme-Like Inhibitory Protein-Long Confers Resistance to CD95-Induced Apoptosis in Hematopoietic Cancer Cell Lines The Journal of Immunology. ,vol. 168, pp. 2544- 2553 ,(2002) , 10.4049/JIMMUNOL.168.5.2544
Masanobu Tsubaki, Yuzuru Yamazoe, Masashi Yanae, Takao Satou, Tatsuki Itoh, Junichi Kaneko, Yasuhiro Kidera, Kenzo Moriyama, Shozo Nishida, Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma. Cytokine. ,vol. 54, pp. 100- 107 ,(2011) , 10.1016/J.CYTO.2011.01.005
Bokyung Sung, Ajaikumar B. Kunnumakkara, Gautam Sethi, Preetha Anand, Sushovan Guha, Bharat B. Aggarwal, Curcumin Circumvents Chemoresistance in vitro and Potentiates the Effect of Thalidomide and Bortezomib against Human Multiple Myeloma in Nude Mice Model Molecular Cancer Therapeutics. ,vol. 8, pp. 959- 970 ,(2009) , 10.1158/1535-7163.MCT-08-0905
Sundar Jagannath, Robert A. Kyle, Antonio Palumbo, David S. Siegel, Sonia Cunningham, James Berenson, The Current Status and Future of Multiple Myeloma in the Clinic Clinical Lymphoma, Myeloma & Leukemia. ,vol. 10, pp. 28- 43 ,(2010) , 10.3816/CLML.2010.N.003
Daniela Marazziti, Angela Gallo, Elisabetta Golini, Rafaele Matteoni, Glauco P. Tocchini-Valentini,, Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis. Genomics. ,vol. 53, pp. 315- 324 ,(1998) , 10.1006/GENO.1998.5433