Reduced accumulation of drug in Candida krusei accounts for itraconazole resistance.
作者： K Venkateswarlu , D W Denning , N J Manning , S L Kelly
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摘要: Due to intrinsic resistance Candida krusei is emerging as a systemic pathogen in AIDS patients undergoing fluconazole therapy, but acquired itraconazole has not been studied biochemically. We report here studies on the basis for azole and sterol composition C. krusei. An itraconazole-resistant isolate showed reduced susceptibility drugs vitro growth inhibition studies. Accumulation of 14 alpha-methyl-3,6-diol under treatment was associated with arrest. In ergosterol biosynthesis type II binding suggested no alteration affinity target enzyme, cytochrome P-450 alpha-demethylase, resistant isolate. Resistance decreased intracellular content drug
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