Bladder cancer risk: Use of the PLCO and NLST to identify a suitable screening cohort

摘要: Abstract Purpose Bladder cancer (BC) screening is not accepted in part owing to low overall incidence. We used the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) National Lung (NLST) identify optimal high-risk populations most likely benefit from screening. Materials methods Data were extracted PLCO NLST stratify risk of BC by population, sex, race, age at inclusion, smoking status. Incidence rates between groups compared using chi-square test. Results was identified 1,430/154,898 patients 439/53,173 NLST. BCs grade III/IV 36.8% 41.3%. significantly higher men than women (PLCO: 1.4 vs. 0.31/1,000 person-years NLST: 1.84 0.6/1,000 person-years, both P Conclusions Men older 60 years with a history of>30 PY had incidence more 2/1,000 which could serve as an excellent population for trials. Sex differences cannot be readily explained exposure tobacco, sex disparity persisted regardless intensity.