Heavy Cigarette Smoking and Aggressive Bladder Cancer at Initial Presentation.
作者： Eugene J. Pietzak , Phillip Mucksavage , Thomas J. Guzzo , S. Bruce Malkowicz
DOI: 10.1016/J.UROLOGY.2015.05.040
关键词:
摘要: Objective To identify the impact of smoking intensity on tumor characteristics at time initial bladder cancer diagnosis. Methods We retrospectively reviewed our institution's prospective database patients diagnosed with from 1987 to 2009. Only urothelial cell carcinoma and recorded tobacco history were included. Patients stratified by into nonsmokers, light smokers (≤30 pack-years), heavy (>30 pack-years). An additional analysis was performed looking meeting National Lung Cancer Screening Trial (NLCST) criteria (55- 74-year-old with ≥30 pack-years and Results identified 197 (26.6%) 251 (33.9%) smokers, 292 (39.5%) smokers. Males more likely be (44.5% vs 23.6%, P ≤.01). Compared nonsmokers tumors in high grade a advanced clinical stage. Heavy present muscle-invasive (MIBC) When compared odds ratio for presenting MIBC 1.18 (95% confidence interval = 0.68-2.1) 1.38 1.06-1.8) Of 793 adequate information analysis, 184 (23.2%) met NLCST criteria. Those most male, gross hematuria, have that muscle invasive. eligibility remained associated multivariate analysis. Conclusion are high-grade detrusor invasion presentation.
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