An analysis of the expression locus of long-term potentiation in hippocampal CA1 neurons

摘要: Long-term potentiation (LTP) has long been understood as an increase in the potency of a synaptic connection between two neurons. In this study, we combine previously developed two-stage cascade model with electrophysiological recordings rat hippocampal CA1 pyramidal cells both before and after LTP to analyze linear nonlinear contributions pre post-synaptic partners strengthening their connectivity. The result suggests that major expression locus exists side. Additionally, report reveals should be not only traditional view change magnitude communication cells, but also temporal coding properties information exchange.