Cross-linking of dialdehyde carboxymethyl cellulose with silk sericin to reinforce sericin film for potential biomedical application.

摘要: Developing biomaterials based on the natural biomacromolecule silk sericin from Bombyx mori cocoon is of great interest for biomedical application. Dialdehyde carboxymethyl cellulose (DCMC) derived periodate oxidation carboxy- methyl cellulose. Here, we developed a novel strategy cross-linking with DCMC via Schiff's base reaction. Fourier transform infrared spectroscopy and scanning electron microscopy indicated formation blending DCMC. The mechanical properties tests suggested covalent effectively enhanced tensile strength sericin. swelling test water contact angle DCMC/SS film had excellent hydrophilicity, swellability. Additionally, demonstrated blood compatibility, cytocompatibility promoting cell proliferation activity by hemolysis ratio analysis, adhesion, cells viability assays. prepared has shown promise in applications such as wound dressing, artificial skin tissue engineering.