Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis.

摘要: The material properties of cancellous bone from patients with osteoporosis (OP) or osteoarthritis (OA) were determined and compared normal controls. Samples selected defined sites in human femoral heads which are subjected to different loads vivo. Overall, OP had the lowest stiffness OA highest, this same order was reflected apparent densities bone, being most dense least. Normal found have very similar stiffness-density relationships composition. However, differed significantly normal. increased more slowly density its reduced. These findings due an altered composition mass fraction mineral is 12% less than There also greater site variation both density, suggesting sensitivity applied load. results support concept that a loss bone. They provide evidence for hypothesis is, at least partly, disease proliferation defective increase stiffness.